Pawlowic lab Papers
van Voorhis W, Siwila J, Kissinger JC, Vásquez NB, Robinson G, Baptista R, Khan A, Guérin A, Chang YW, Noor Z, Marzook NB, Vinayak S, Arnold S, Marie C, Choy RKM, Pawlowic MC, Jumani RS. The first Cryptosporidium meeting: a concerted effort to fight cryptosporidiosis. Trends Parasitol. 2024 May 2:S1471-4922(24)00088-6. doi: 10.1016/j.pt.2024.04.005. Epub ahead of print. PMID: 38702267.
Khan, E.V.C. Alves-Ferreira, H. Vogel, S. Botchie, I. Ayi, M.C. Pawlowic, G. Robertson, R.M. Chalmers, H. Lorenzi, M.E. Grigg. Phylogenetic reconstruction of Cryptosporidium spp. captured directly from clinical samples reveals extensive genetic diversity. biorxiv, https://doi.org/10.1101/2024.04.17.589752
Hanna JC, Corpas-Lopez V%, Seizova S%, Colon BL, Bacchetti R, Hall GMJ, Sands EM, Robinson L, Baragaña B, Wyllie S*, Pawlowic MC*. Mode of action studies confirm on-target engagement of lysyl-tRNA synthetase inhibitor and lead to new selection marker for Cryptosporidium. Front Cell Infect Microbiol. 2023 Aug 4;13:1236814. doi: 10.3389/fcimb.2023.1236814. PMID: 37600947; PMCID: PMC10436570. %equal contribution *corresponding authors.
Gilbert IH, Vinayak S, Striepen B, Manjunatha UH, Khalil IA, Van Voorhis WC; Cryptosporidiosis Therapeutics Advocacy Group CTAG; Cryptosporidiosis Therapeutics Advocacy CTAG. Safe and effective treatments are needed for cryptosporidiosis, a truly neglected tropical disease. BMJ Glob Health. 2023 Aug;8(8):e012540. doi: 10.1136/bmjgh-2023-012540. PMID: 37541693.
Gissot M, Pawlowic MC, Modrzynska KK, Francia ME. Editorial: Molecular Basis of Stage Conversion in Apicomplexan Parasites. Front Cell Infect Microbiol. 2021 Apr 16;11:680184. doi: 10.3389/fcimb.2021.680184. PMID: 33937107; PMCID: PMC8085330.
Innes EA, Chalmers RM, Wells B, Pawlowic MC. A One Health Approach to Tackle Cryptosporidiosis. Trends Parasitol. 2020 Mar;36(3):290-303. doi: 10.1016/j.pt.2019.12.016. Epub 2020 Jan 23. PMID: 31983609; PMCID: PMC7106497.
Previous papers by Mattie
Mattie Christine Pawlowic on PubMed and Google Scholar
Basu S, Pawlowic MC, Hsu FF, Thomas G, Zhang K. Ethanolaminephosphate cytidylyltransferase is essential for survival, lipid homeostasis and stress tolerance in Leishmania major. PLoS Pathog. 2023 Jul 28;19(7):e1011112. doi: 10.1371/journal.ppat.1011112. PMID: 37506172; PMCID: PMC10411802.
Moitra S, Basu S, Pawlowic M, Hsu FF, Zhang K. De Novo Synthesis of Phosphatidylcholine Is Essential for the Promastigote But Not Amastigote Stage in Leishmania major. Front Cell Infect Microbiol. 2021 Mar 12;11:647870. doi: 10.3389/fcimb.2021.647870. PMID: 33777852; PMCID: PMC7996062.
Pawlowic MC, Somepalli M, Sateriale A, Herbert GT, Gibson AR, Cuny GD, Hedstrom L, Striepen B. Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cell. Proc Natl Acad Sci USA. 2019 Oct 15; 116(42): 21160-21165. doi: 10.1073/pnas.1908239116. PMID: 31570573
Sateriale A., Pawlowic M., Vinayak S., Brooks C., Striepen B. (2020) Genetic Manipulation of Cryptosporidium parvum with CRISPR/Cas9. In: Mead J., Arrowood M. (eds) Cryptosporidium. Methods in Molecular Biology, vol 2052. Humana, New York, NY. PMID: 31452165
Moitra S, Pawlowic MC, Hsu F, Zhang K. Phosphatidylcholine synthesis through cholinephosphate cytidylyltransferase is dispensable in Leishmania major. Scientific Reports. 2019 May 20; 9(1): 7602. PMID: 31110206
Pawlowic MC, Vinayak S, Sateriale A, Brooks CF, Striepen B. Generating and Maintaining Transgenic Cryptosporidium parvum Curr Protoc Microbiol. 2017 Aug 11;46:20B.2.1-20B.2.32. doi: 10.1002/cpmc.33. PMID: 28800157
Pawlowic MC, Hsu FF, Moitra S, Biyani N, Zhang K. Plasmenylethanolamine synthesis in Leishmania major. Mol Microbiol. 2016 Jul; 101(2): 238-49. doi: 10.1111/mmi.13387. Epub 2016 May 6. PMID: 27062077
Vinayak S*, Pawlowic MC*, Sateriale A*, Brooks CF, Studstill CJ, Bar-Peled Y, Cipriano MJ, Striepen B. Genetic modification of the diarrhoeal pathogen Cryptosporidium parvum. 2015 Jul 23; 523(7561): 477-80. doi: 10.1038/nature14651. PMID: 26176919 *These authors contributed equally to this work.
Featured: Nature News and Views, Trends in Parasitology
Zhang O, Hsu FF, Xu W, Pawlowic M, Zhang K. Sphingosine kinase A is a pleiotropic and essential enzyme for Leishmania survival and virulence. Mol Microbiol. 2013 Nov; 90(3): 489-501. doi: 10.1111/mmi.12378. PMID: 23980754
Pawlowic MC, Zhang K. Leishmania parasites possess a platelet-activating factor acetylhydrolase important for virulence. Mol Biochem Parasitol. 2012 Nov; 186(1): 11-20. doi: 10.1016/j.molbiopara.2012.08.005. PMID: 22954769
Zhang O, Wilson MC, Xu W, Hsu FF, Turk J, Kuhlmann FM, Wang Y, Soong L, Key P, Beverley SM, Zhang K. Degradation of host sphingomyelin is essential for Leishmania virulence. PLoS Pathog. 2009 Dec; 5(12): e1000692. doi:10.1371/journal.ppat.1000692. PMID: 20011126
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